GrippeBresilV1, Main, Exploration, bibRecord, 000290

Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015.

Identifieur interne : 000290 ( Main/Exploration ); précédent : 000289; suivant : 000291

Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015.

Auteurs : Patricia Filippsen Favaro [Brésil] ; Wilson Roberto Fernandes [Brésil] ; Dilmara Reischak [Brésil] ; Paulo Eduardo Brandão [Brésil] ; Sheila Oliveira De Souza Silva [Brésil] ; Leonardo José Richtzenhain [Brésil]

Source :

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [ 1678-4405 ]

RBID : pubmed:29100932

Descripteurs français

KwdFr :
- Analyse de séquence d'ADN, Animaux, Brésil (épidémiologie), Equus caballus, Flambées de maladies, Glycoprotéine hémagglutinine du virus influenza (génétique), Génotype, Hôpitaux vétérinaires, Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (virologie), Infections à Orthomyxoviridae (épidémiologie), Maladies des chevaux (virologie), Maladies des chevaux (épidémiologie), Orthomyxoviridae, Protéines virales (génétique), Sialidase (génétique), Sous-type H3N8 du virus de la grippe A (), Sous-type H3N8 du virus de la grippe A (génétique), Sous-type H3N8 du virus de la grippe A (isolement et purification), Substitution d'acide aminé, Variation génétique, Évolution moléculaire.
MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Protéines virales, Sialidase, Sous-type H3N8 du virus de la grippe A.
- isolement et purification : Sous-type H3N8 du virus de la grippe A.
- médecine vétérinaire : Infections à Orthomyxoviridae.
- virologie : Infections à Orthomyxoviridae, Maladies des chevaux.
- épidémiologie : Brésil, Infections à Orthomyxoviridae, Maladies des chevaux.
- Analyse de séquence d'ADN, Animaux, Equus caballus, Flambées de maladies, Génotype, Hôpitaux vétérinaires, Orthomyxoviridae, Sous-type H3N8 du virus de la grippe A, Substitution d'acide aminé, Variation génétique, Évolution moléculaire.

English descriptors

KwdEn :
- Amino Acid Substitution, Animals, Brazil (epidemiology), Disease Outbreaks, Evolution, Molecular, Genetic Variation, Genotype, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Horse Diseases (epidemiology), Horse Diseases (virology), Horses, Hospitals, Animal, Influenza A Virus, H3N8 Subtype (classification), Influenza A Virus, H3N8 Subtype (genetics), Influenza A Virus, H3N8 Subtype (isolation & purification), Neuraminidase (genetics), Orthomyxoviridae, Orthomyxoviridae Infections (epidemiology), Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Sequence Analysis, DNA, Viral Proteins (genetics).
MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Neuraminidase, Viral Proteins.
- classification : Influenza A Virus, H3N8 Subtype.
- epidemiology : Brazil, Horse Diseases, Orthomyxoviridae Infections.
- genetics : Influenza A Virus, H3N8 Subtype.
- isolation & purification : Influenza A Virus, H3N8 Subtype.
- veterinary : Orthomyxoviridae Infections.
- virology : Horse Diseases, Orthomyxoviridae Infections.
- Amino Acid Substitution, Animals, Disease Outbreaks, Evolution, Molecular, Genetic Variation, Genotype, Horses, Hospitals, Animal, Orthomyxoviridae, Sequence Analysis, DNA.

Abstract

Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak.

DOI: 10.1016/j.bjm.2017.07.003
PubMed: 29100932

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000053
to stream Main, to step Curation: 000053

Le document en format XML

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<front><div type="abstract" xml:lang="en">Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak.</div>
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<DateCompleted><Year>2018</Year>
<Month>08</Month>
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<Title>Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]</Title>
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<ArticleTitle>Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015.</ArticleTitle>
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<Abstract><AbstractText>Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuraminidase amino acid sequences were compared with the recent isolates from North and South America and the World Organisation for Animal Health recommended Florida Clade 1 vaccine strain. The hemagglutinin amino acid sequences had nine substitutions, compared with the vaccine strain. Two of them were in antigenic site A (A138S and G142R), one in antigenic site E (R62K) and another not in antigenic site (K304E). The four substitutions changed the hydrophobicity of hemagglutinin. Three distinct genetic variants were identified during the outbreak. Eleven variants were found in four quasispecies, which suggests the equine influenza virus evolved during the outbreak. The use of an out of date vaccine strain or updated vaccines without the production of protective antibody titers might be the major contributing factors on virus dissemination during this outbreak.</AbstractText>
<CopyrightInformation>Copyright © 2017 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Favaro</LastName>
<ForeName>Patricia Filippsen</ForeName>
<Initials>PF</Initials>
<AffiliationInfo><Affiliation>Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo, SP, Brazil. Electronic address: patriciafilippsen@gmail.com.</Affiliation>
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<Author ValidYN="Y"><LastName>Fernandes</LastName>
<ForeName>Wilson Roberto</ForeName>
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<AffiliationInfo><Affiliation>Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica, São Paulo, SP, Brazil.</Affiliation>
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<ForeName>Dilmara</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Ministério da Agricultura, Pecuária e Abastecimento, Laboratório Nacional Agropecuário, Campinas, SP, Brazil.</Affiliation>
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Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015.

Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015.

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